The organ in the body primarily responsible for detoxification is the liver. The liver plays a vital role in metabolizing nutrients, regulating chemical levels in the blood, and filtering harmful substances. It processes toxins, drugs, and waste products, converting them into less harmful substances or preparing them for excretion through urine or bile. The liver also produces bile, which aids in the digestion of fats, and synthesizes important proteins for blood clotting and immune system functions. Its ability to regenerate makes the liver pivotal to maintaining overall health, emphasizing its significance in detoxifying the bloodstream.