The human organ responsible for detoxification is the liver. This vital organ plays a crucial role in metabolizing drugs, alcohol, and other toxins that enter the body. The liver filters blood coming from the digestive tract before it is sent to the rest of the body, converting harmful substances into safer compounds. Additionally, it produces bile, which helps in digesting fats and removing waste. The liver's ability to regenerate makes it unique; it can recover from damage as long as it is not severely compromised, emphasizing its importance in maintaining overall health.