The famous painting that features a woman with a mysterious smile is the "Mona Lisa," created by the renowned artist Leonardo da Vinci. Painted between 1503 and 1506, this masterpiece is known for its enigmatic expression, captivating viewers for centuries. Housed in the Louvre Museum in Paris, the Mona Lisa is often noted for its detailed background, sfumato technique, and the subject’s subtle smile, which many interpret differently. The painting's fame has led to numerous interpretations, parodies, and cultural references, solidifying its status as one of the most famous artworks in history.