The plant commonly used as a natural remedy for headaches is the feverfew (Tanacetum parthenium). Feverfew has a long history of use in traditional medicine for alleviating migraines and tension-type headaches. The active compounds in feverfew are believed to inhibit inflammatory substances and affect serotonin levels in the brain, which may help prevent headache onset. While some individuals report relief from using feverfew, scientific research varies, and it may not work for everyone. Most commonly, feverfew is consumed in the form of capsules, teas, or fresh leaves to achieve its medicinal benefits.