The organ primarily responsible for detoxification in the body is the liver. The liver plays a crucial role in filtering blood, metabolizing nutrients, and detoxifying chemicals and drugs. It converts harmful substances into less toxic forms, which can then be excreted by the body. Furthermore, the liver synthesizes proteins vital for blood clotting and other functions. This multitasking organ ensures that metabolic waste and toxins do not accumulate in the bloodstream, maintaining overall health.