The organ in the human body responsible for digestion is the digestive system, which includes several key organs. The process begins in the mouth, where food is mechanically broken down and mixed with saliva. It then travels to the stomach, where gastric juices further digest the food. The small intestine plays a central role, as it absorbs nutrients into the bloodstream. Other organs, such as the liver and pancreas, contribute important enzymes and bile for digestion. Finally, the large intestine reabsorbs water and prepares waste for elimination. Overall, this complex system ensures that our bodies receive necessary nutrients.