The human organ primarily responsible for detoxification is the liver. The liver is vital in processing various substances, including drugs, alcohol, and metabolic waste products. It converts toxic substances into harmless ones through biochemical reactions and then excretes them into bile or the bloodstream for elimination. Additionally, the liver plays a role in producing important proteins, regulating metabolism, and storing nutrients. Given its central role in maintaining overall health, liver function is critical to the body's ability to filter out harmful substances and maintain a stable internal environment, known as homeostasis.