The primary substance used to construct a house is typically concrete, wood, or a combination of both. Concrete is widely favored for its durability and strength and is often used for foundations, walls, and other structural elements. Wood provides aesthetic appeal, insulation, and is commonly used for frames, floors, and roofs. The choice of materials may vary based on regional availability, climate considerations, and architectural style preferences. Thus, modern construction often balances these factors to create safe, functional, and visually appealing homes.