The ancient structure associated with the constellation Orion is the Great Pyramid of Giza. This iconic pyramid is part of the Giza pyramid complex in Egypt and is believed to be aligned with the stars in the Orion constellation. The ancient Egyptians associated the constellation Orion with Osiris, the god of the afterlife, and the pyramids were constructed as tombs for pharaohs to facilitate their journey to the afterlife. The alignment of the Great Pyramid and other pyramids with Orion reflects the Egyptians' deep understanding of astronomy and their desire to establish a connection between the earth and the heavens.